• Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: A meta-analysis in Europeans 

      Mauschitz, Matthias M.; Verzijden, Timo; Schuster, Alexander K.; Elbaz, Hisham; Pfeiffer, Norbert; Khawaja, Anthony; Luben, Robert N.; Foster, Paul J.; Rauscher, Franziska G.; Wirkner, Kerstin; Kirsten, Toralf; Jonas, Jost B.; Bikbov, Mukharram M.; Hogg, Ruth; Peto, Tunde; Cougnard-Grégoire, Audrey; Bertelsen, Geir; Erke, Maja Gran; Topouzis, Fotis; Giannoulis, Dimitrios A.; Brandl, Caroline; Heid, Iris M.; Creuzot-Garcher, Catherine P.; Gabrielle, Pierre-Henry; Hense, Hans-Werner; Pauleikhoff, Daniel; Barreto, Patricia; Coimbra, Rita; Piermarocchi, Stefano; Daien, Vincent; Holz, Frank G.; Delcourt, Cecile; Finger, Robert P. (Journal article; Tidsskriftartikkel, 2022-11-07)
      <p><i>Background/aims</i> To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. <p><i>Methods</i> We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent ...
    • Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium 

      Vergroesen, Joëlle E.; Schuster, Alexander K.; Stuart, Kelsey V.; Asefa, Nigus G.; Cougnard-Grégoire, Audrey; Delcourt, Cécile; Schweitzer, Cédric; Barreto, Patrícia; Coimbra, Rita; Foster, Paul J.; Luben, Robert N.; Pfeiffer, Norbert; Stingl, Julia V.; Kirsten, Toralf; Rauscher, Franziska G.; Wirkner, Kerstin; Jansonius, Nomdo M.; Arnould, Louis; Creuzot-Garcher, Catherine P.; Stricker, Bruno H.; Keskini, Christina; Topouzis, Fotis; Bertelsen, Geir; Eggen, Anne Elise; Bikbov, Mukharram M.; Jonas, Jost B.; Klaver, Caroline C.W.; Ramdas, Wishal D.; Khawaja, Anthony P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-06)
      Purpose - To investigate the association of commonly used systemic medications with glaucoma and intraocular pressure (IOP) in the European population.<p> <p>Design - Meta-analysis of 11 population-based cohort studies of the European Eye Epidemiology Consortium.<p> <p>Participants - The glaucoma analyses included 143 240 participants and the IOP analyses included 47 177 participants.<p> <p>Methods ...
    • Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies 

      van der Heide, Frank C. T.; Khawaja, Anthony; Berendschot, Tos T. J. M.; Littlejohns, Thomas J.; Kuźma, Elżbieta; Luben, Robert; Patel, Praveen J.; Foster, Paul J.; Bertelsen, Geir; von Hanno, Therese; Johnsen, Bente; Schirmer, Henrik; Rebouças, Sara C. L.; Grasset, Leslie; Delcourt, Cécile; Helmer, Catherine; Stehouwer, Coen D. A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)
      INTRODUCTION - Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).<p> <p>METHODS - We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = ...
    • Clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery 

      Lind, Caroline; Olsen, Karina; Angelsen, Nina K.; Krefting, Einar A.; Fossen, Kristian; Gravningen, Kirsten; Depoorter, Eliza; Vandamme, Peter; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)
      Background - Postoperative endophthalmitis is a rare but dreaded complication of intraocular surgery and often results in severe visual impairment or blindness. The present study describes the clinical course, treatment and visual outcome of an outbreak of Burkholderia contaminans endophthalmitis following cataract surgery.<p> <p>Methods - Among 290 patients who underwent uneventful phacoemulsification ...
    • The decreasing prevalence of nonrefractive visual impairment in older Europeans: a meta-analysis of published and unpublished data 

      Delcourt, Cécile; Le Goff, Mélanie; von Hanno, Therese; Mirshahi, Alireza; Khawaja, Anthony P.; Verhoeven, Virginie J.M.; Hogg, Ruth E.; Anastosopoulos, Eleftherios; Cachulo, Maria Luz; Höhn, René; Wolfram, Christian; Bron, Alain; Miotto, Stefania; Carrière, Isabelle; Colijn, Johanna M.; Buitendijk, Gabriëlle H.S.; Evans, Jennifer; Nitsch, Dorothea; Founti, Panayiota; Yip, Jennifer L.Y.; Pfeiffer, Norbert; Creuzot-Garcher, Catherine; Silva, Rufino; Piermarocchi, Stefano; Topouzis, Fotis; Bertelsen, Geir; Foster, Paul J.; Fletcher, Astrid; Klaver, Caroline C.W.; Korobelnik, Jean-François (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-13)
      <p><i>Topic</i>: To estimate the prevalence of nonrefractive visual impairment and blindness in European persons 55 years of age and older.</p> <p><i>Clinical Relevance</i>: Few visual impairment and blindness prevalence estimates are available for the European population. In addition, many of the data collected in European population-based studies currently are unpublished and have not been ...
    • Epithelial Thickness Mapping in Keratoconic Corneas: Repeatability and Agreement Between CSO MS-39, Heidelberg Anterion, and Optovue Avanti OCT Devices 

      Feng, Yue; Reinstein, Dan Z.; Nitter, Tore; Archer, Timothy J.; McAlinden, Colm; Bertelsen, Geir; Stojanovic, Aleksandar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-01)
      PURPOSE:To assess repeatability and agreement of corneal epithelial thickness mapping in eyes with keratoconus using three optical coherence tomography (OCT) devices featuring different technologies: spectral-domain (SD) OCT combined with Placido disk corneal topography (MS-39), swept-source OCT (Anterion), and SD-OCT (Avanti).<p> <p>METHODS:Three consecutive measurements were acquired with the ...
    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...
    • Heidelberg Anterion Swept-Source OCT Corneal Epithelial Thickness Mapping: Repeatability and Agreement With Optovue Avanti 

      Feng, Yue; Reinstein, Dan Z.; Nitter, Tore A.; Archer, Timothy J.; McAlinden, Colm; Chen, Xiangjun; Utheim, Tor Paaske; Bertelsen, Geir; Stojanovic, Aleksandar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-01)
      <p><b> PURPOSE:</b> To assess the repeatability of corneal epithelial thickness mapping in virgin, post-laser refractive surgery (PLRS), and keratoconic eyes using a novel swept-source optical coherence tomographer (SS-OCT), and to determine the agreement of the measurements with a validated spectral-domain (SD) OCT. <p><b> METHODS:</b> Analysis of 90 virgin, 46 PLRS, and 122 keratoconic eyes ...
    • Increasing prevalence of myopia in Europe and the impact of education 

      Williams, Katie M.; Bertelsen, Geir; Cumberland, Phillippa; Wolfram, Christian; Verhoeven, Virginie J.M.; Anastasopoulos, Eleftherios; Buitendijk, Gabriëlle H.S.; Cougnard-Grégoire, Audrey; Creuzot-Garcher, Catherine; Erke, Maja Gran; Hogg, Ruth; Höhn, René; Hysi, Pirro; Khawaja, Anthony P.; Korobelnik, Jean-François; Ried, Janina; Vingerling, Johannes R.; Bron, Alain; Dartigues, Jean-François; Fletcher, Astrid; Hofman, Albert; Kuijpers, Robert W.A.M.; Luben, Robert N; Oxele, Konrad; Topouzis, Fotis; Hanno, Therese von; Mirshahi, Alireza; Foster, Paul J.; Van Duijn, Cornelia M.; Pfeiffer, Norbert; Delcourt, Cécile; Klaver, Caroline C.W.; Rahi, Jugnoo; Hammond, Christopher J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07)
      Purpose: To investigate whether myopia is becoming more common across Europe and explore whether increasing education levels, an important environmental risk factor for myopia, might explain any temporal trend. <p>Design: Meta-analysis of population-based, cross-sectional studies from the European Eye Epidemiology (E3 ) Consortium. <p>Participants: The E3 Consortium is a collaborative network ...
    • Macular Layer Thickness and Effect of BMI, Body Fat, and Traditional Cardiovascular Risk Factors: The Tromsø Study 

      von Hanno, Therese; Hareide, Live Lund; Småbrekke, Lars; Morseth, Bente; Sneve, Monica; Erke, Maja Gran; Mathiesen, Ellisiv B.; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-12)
      PURPOSE. The purpose of this study was to investigate associations between cardiovascular risk factors and the thickness of retinal nerve fiber layer (RNFL), ganglion cell-inner plexiform layer (GCIPL), and outer retina layers (ORL).<p> <p>METHODS. In this population-based study, we included participants from the Tromsø Study: Tromsø6 (2007 to 2008) and Tromsø7 (2015 to 2016). Persons with ...
    • Macular thickness in healthy eyes of adults (N=4508) and relation to sex, age and refraction: The Tromsø Eye Study (2007-08) 

      Hanno, Therese von; Lade, Anette Caroline; Mathiesen, Ellisiv B.; Peto, Tunde; Njølstad, Inger; Bertelsen, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-18)
      Purpose: To provide sex-stratified normative data on retinal thickness and study the relationship with sex, age and refractive status. Methods: Population-based study including 2617 women and 1891 men, aged 38– 87 (mean 61 8) years, without diabetes, glaucoma and retinal diseases, and spherical equivalent refraction (SER) within 6 dioptres. Retinal thickness was measured with optical coherence ...
    • Prevalence of refractive error in Europe: the European Eye Epidemiology (E(3)) Consortium 

      Williams, Katie M.; Verhoeven, Virginie J.M.; Cumberland, Phillippa; Bertelsen, Geir; Wolfram, Christian; Buitendijk, Gabriëlle H.S.; Hofman, Albert; Van Duijn, Cornelia M.; Vingerling, Johannes R.; Kuijpers, Robert W.A.M.; Höhn, René; Mirshahi, Alireza; Khawaja, Anthony P.; Luben, Robert N.; Erke, Maja Gran; Hanno, Therese von; Mahroo, Omar; Hogg, Ruth; Gieger, Christian; Cougnard-Grégoire, Audrey; Anastasopoulos, Eleftherios; Bron, Alain; Dartigues, Jean-François; Korobelnik, Jean-François; Creuzot-Garcher, Catherine; Topouzis, Fotis; Delcourt, Cecile; Rahi, Jugnoo; Meitinger, Thomas; Fletcher, Astrid; Foster, Paul J.; Pfeiffer, Norbert; Klaver, Caroline C.W.; Hammond, Christopher J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-18)
      To estimate the prevalence of refractive error in adults across Europe. Refractive data (mean spherical equivalent) collected between 1990 and 2013 from fifteen population-based cohort and cross-sectional studies of the European Eye Epidemiology (E3 ) Consortium were combined in a random effects meta-analysis stratified by 5-year age intervals and gender. Participants were excluded if they were ...
    • Retinal Vessel Width Measurement at Branchings Using an Improved Electric Field Theory-Based Graph Approach 

      Xu, Xiayu; Reinhardt, Joseph M.; Hu, Qiao; Bakall, Benjamin; Tlucek, Paul S.; Bertelsen, Geir; Abràmoff, Michael D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The retinal vessel width relationship at vessel branch points in fundus images is an important biomarker of retinal and systemic disease. We propose a fully automatic method to measure the vessel widths at branch points in fundus images. The method is a graph-based method, in which a graph construction method based on electric field theory is applied which specifically deals with complex branching ...
    • Retinopathy with and without diabetes: Risk factors and visual impairment. 

      Bertelsen, Geir (Doctoral thesis; Doktorgradsavhandling, 2013-03-22)
      Diabetic retinopathy is a well-known complication of diabetes and a major cause of visual impairment and blindness in developed countries. We explored visual impairment and diabetic retinopathy among participants with diabetes in the Tromsø Eye Study. The prevalence of visual impairment (corrected Snellen visual acuity < 20/40) was 4.1% in the better-seeing eye. We found no legally blind participants. ...
    • Trajectories of recall memory as predictive of hearing impairment: A longitudinal cohort study 

      Maharani, Asri; Dawes, Piers; Nazroo, James; Tampubolon, Gindo; Pendleton, Neil; Bertelsen, Geir; Cosh, Suzanne; Cougnard-Grégoire, Audrey; Delcourt, Cécile; Constantinidou, Fofi; Goedegebure, Andre; Helmer, Catherine; Arfan Ikram, M; Klaver, Caroline C.W.; Leroi, Iracema; Meester-Smor, Magda; Nae, Virginie; Oosterloo, Neelke; Schirmer, Henrik; Tiemeier, Henning; von Hanno, Therese (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-18)
      <i>Objectives</i> - Accumulating evidence points to a relationship between hearing function and cognitive ability in later life. However, the exact mechanisms of this relationship are still unclear. This study aimed to characterise latent cognitive trajectories in recall memory and identify their association with subsequent risk of hearing impairment.<p> <p><i>Methods</i> - We analysed data from ...
    • Uveitis in Juvenile Idiopathic Arthritis 18-Year Outcome in the Population-based Nordic Cohort Study 

      Rypdal, Veronika Gjertsen; Glerup, Mia; Songstad, Nils Tomas; Bertelsen, Geir; Christoffersen, Terje; Arnstad, Ellen D.; Aalto, Kristiina; Berntson, Lillemor; Fasth, Anders; Herlin, Troels; Ekelund, Maria; Peltoniemi, Suvi; Toftedal, Peter; Nielsen, Susan; Leinonen, Sanna; Bangsgaard, Regitze; Nielsen, Rasmus; Rygg, Marite; Nordal, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-28)
      <i>Purpose</i> - To assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).<p> <p><i>Design</i> - Population-based, multicenter, prospective JIA cohort, with a cross-sectional assessment of JIA-associated uveitis (JIA-U) 18 years after the onset of JIA.<p> <p><i>Participants</i> - A total of 434 patients with JIA, of whom 96 had uveitis, from defined geographic areas of ...